Simulation of associative learning with the replaced elements model

Associative learning theories can be categorised according to whether they treat the representation of stimulus compounds in an elemental or configural manner. Since it is clear that a simple elemental approach to stimulus representation is inadequate there have been several attempts to produce more elaborate elemental models. One recent approach, the Replaced Elements Model (Wagner, 2003), reproduces many results that have until recently been uniquely predicted by Pearce’s Configural Theory (Pearce, 1994). Although it is possible to simulate the Replaced Elements Model using “standard” simulation programs the generation of the correct stimulus representation is complex. The current paper describes a method for simulation of the Replaced Elements Model and presents the results of two example simulations that show differential predictions of Replaced Elements and Pearce’s Configural Theor

Calcium regulates the rate of rhodopsin disactivation and the primary amplification step in visual transduction.

The kinetics of the light-induced activation of transducin as well as the subsequent disactivation process can be monitored by means of a specific light scattering transient PA. In this communication it is demonstrated that the rate of transducin disactivation is calcium dependent, increasing when the calcium concentration is decreased. As a consequence of the accelerated recovery in low calcium, the time to the peak of the transducin activation process is shortened and the gain of the primary amplification step, i.e. the number of transducin molecules activated per bleached rhodopsin, is reduced. Experiments using hydroxylamine as an artificial quencher of rhodopsin activity suggest that calcium acts upon rhodopsin kinase and not upon the rate of the GTPase. This would indicate that calcium may control visual adaptation not only by regulating guanine cyclase activity, but also by affecting the primary step in the transduction cascade, the rhodopsin-transducin couplin

Watching G proteins at work.

It has been known for over a century that rod photoreceptors in the living retina contract and swell in response to light. Although it is still not known whether this structural light-response is of any functional significance, it has recently been possible to correlate the underlying molecular processes with the activation and deactivation of the photoreceptor G protein, transducin. The technique of light-scattering allows the monitoring of minute changes in cell dimensions, and using this non-invasive experimental approach it can be shown that certain properties of the coupling between transducin and rhodopsin are different in a structurally well-preserved system as compared with rod material used for conventional biochemical studies. Thus, not unlike a psychiatrist, who often learns more about a patient's 'interiors' by observing the body language than by direct interrogation, a biochemist, studying the 'body language' of a cell, may extract information about delicate 'cell interior processes' that would be perturbed by more direct experimental approaches

Effects of scopolamine on matching to sample paradigm and related tests in human subjects

This was a double-blind placebo-controlled study with a cross-over design to examine the effects of scopolamine on cognitive functions in young healthy subjects. Scopolamine hydrobromide was administered subcutaneously to 12 subjects (mean +/- SD age 23.8 +/- 2.2 years) at doses of 0.3 and 0.6 mg in comparison with two placebo conditions. Scopolamine at both doses produced marked sedation as rated by subjects and an observer. In the continuous performance test, vigilance was impaired by both doses of scopolamine. The span of apprehension test showed differing results (only the high dose of scopolamine showed a performance decrement only in the three-character version of the span of apprehension test). Significant impairment by both doses of scopolamine was seen in immediate and delayed free recall, continuous visual recognition, running word recognition and running picture recognition. While scopolamine caused a significant slowing in average reaction times for simultaneous matching as well as for delayed matching, subjects made more errors under scopolamine compared to placebo only in delayed matching, not in simultaneous matching. Also, the main outcome of matching to sample showed significant effects only in delayed matching, not in simultaneous matching. Notable in this study is the incongruity between the simultaneous matching test and the span of apprehension test on the one hand and the other cognitive tests used on the other. These results demonstrated that scopolamine has a greater effect on memory than on attention. Thus, the scopolamine-induced effects in the present study seem to be more relevant to Alzheimer's disease in an advanced phase than to normal aging. Copyright (C) 2003 S. Karger AG, Basel

Advanced gearbox technology

An advanced 13,000 HP, counterrotating (CR) gearbox was designed and successfully tested to provide a technology base for future designs of geared propfan propulsion systems for both commercial and military aircraft. The advanced technology CR gearbox was designed for high efficiency, low weight, long life, and improved maintainability. The differential planetary CR gearbox features double helical gears, double row cylindrical roller bearings integral with planet gears, tapered roller prop support bearings, and a flexible ring gear and diaphragm to provide load sharing. A new Allison propfan back-to-back gearbox test facility was constructed. Extensive rotating and stationary instrumentation was used to measure temperature, strain, vibration, deflection and efficiency under representative flight operating conditions. The tests verified smooth, efficient gearbox operation. The highly-instrumented advanced CR gearbox was successfully tested to design speed and power (13,000 HP), and to a 115 percent overspeed condition. Measured CR gearbox efficiency was 99.3 percent at the design point based on heat loss to the oil. Tests demonstrated low vibration characteristics of double helical gearing, proper gear tooth load sharing, low stress levels, and the high load capacity of the prop tapered roller bearings. Applied external prop loads did not significantly affect gearbox temperature, vibration, or stress levels. Gearbox hardware was in excellent condition after the tests with no indication of distress

Detection of SUSY Signals in Stau Neutralino Co-annihilation Region at the LHC

We study the prospects of detecting the signal in the stau neutralino co-annihilation region at the LHC using tau leptons. The co-annihilation signal is characterized by the stau and neutralino mass difference (dM) to be 5-15 GeV to be consistent with the WMAP measurement of the cold dark matter relic density as well as all other experimental bounds within the minimal supergravity model. Focusing on tau's from neutralino_2 --> tau stau --> tau tau neutralino_1 decays in gluino and squark production, we consider inclusive MET+jet+3tau production, with two tau's above a high E_T threshold and a third tau above a lower threshold. Two observables, the number of opposite-signed tau pairs minus the number of like-signed tau pairs and the peak position of the di-tau invariant mass distribution, allow for the simultaneous determination of dM and M_gluino. For dM = 9 GeV and M_gluino = 850 GeV with 30 fb^-1 of data, we can measure dM to 15% and M_gluino to 6%.Comment: 4 pages LaTex, 3 figures. To appear in Proceedings of SUSY06, the 14th International Conference on Supersymmetry and the Unification of Fundamental Interactions, UC Irvine, California, 12-17 June 2006. A typo in a reference is correcte

Knockouts, Robustness and Cell Cycles

The response to a knockout of a node is a characteristic feature of a networked dynamical system. Knockout resilience in the dynamics of the remaining nodes is a sign of robustness. Here we study the effect of knockouts for binary state sequences and their implementations in terms of Boolean threshold networks. Beside random sequences with biologically plausible constraints, we analyze the cell cycle sequence of the species Saccharomyces cerevisiae and the Boolean networks implementing it. Comparing with an appropriate null model we do not find evidence that the yeast wildtype network is optimized for high knockout resilience. Our notion of knockout resilience weakly correlates with the size of the basin of attraction, which has also been considered a measure of robustness.Comment: 11 pages, 3 figures, 3 table

Quantum radiation reaction force on a one-dimensional cavity with two relativistic moving mirrors

We consider a real massless scalar field inside a cavity with two moving mirrors in a two-dimensional spacetime, satisfying Dirichlet boundary condition at the instantaneous position of the boundaries, for arbitrary and relativistic laws of motion. Considering vacuum as the initial field state, we obtain formulas for the exact value of the energy density of the field and the quantum force acting on the boundaries, which extend results found in previous papers. For the particular cases of a cavity with just one moving boundary, non-relativistic velocities, or in the limit of infinity length of the cavity (a single mirror), our results coincide with those found in the literature.Comment: 6 pages 9 figure

Merging of globular clusters within inner galactic regions. II. The Nuclear Star Cluster formation

In this paper we present the results of two detailed N-body simulations of the interaction of a sample of four massive globular clusters in the inner region of a triaxial galaxy. A full merging of the clusters takes place, leading to a slowly evolving cluster which is quite similar to observed Nuclear Clusters. Actually, both the density and the velocity dispersion profiles match qualitatively, and quantitatively after scaling, with observed features of many nucleated galaxies. In the case of dense initial clusters, the merger remnant shows a density profile more concentrated than that of the progenitors, with a central density higher than the sum of the central progenitors central densities. These findings support the idea that a massive Nuclear Cluster may have formed in early phases of the mother galaxy evolution and lead to the formation of a nucleus, which, in many galaxies, has indeed a luminosity profile similar to that of an extended King model. A correlation with galactic nuclear activity is suggested.Comment: 18 pages, 10 figures, 3 tables. Submitted to ApJ, main journa